I don't have to do it for many of my packages, but I do regularly check ABI compliance before performing an update so I know if I need to rebuild dependencies or not. 

Currently my workflow is something like:

$ cd abicompare/<pkgname>

$ mkdir <oldver> <newver>

$ cd <oldver> (unpack pakage and -devel package)

(same for <newver>)

$ abi-compliance-checker -l <package> -vnum <newver> -dump <newver>

$ abi-compliance-checker -l <package> -vnum <oldver> -dump <oldver>

$ abi-compliance-checker -l <package> -old <oldabidump_dir> -new <newabidump_dir>

$ scp -r <html_report> <fedorapeople>:public_html/compatibility_report/

It would be REALLY nice to automate this to any extent possible PRIOR to actually building a package (fedpkg <scratch-build | mockbuild>).

I'm partial to abi-compliance-checker because I maintain it and I know how to interpret the results but any equivalent tool would be fine :)

Do you know the existence of fedabipkgdiff [1] and rfabipkgdiff [2].

The funny part (for me) is that both commands aren't in fedpkg or rfpkg 

[1] 

rpm -qf /usr/bin/fedabipkgdiff

libabigail-1.0-1.fc26.x86_64 

[2]

rpm -qf /usr/bin/rfabipkgdiff  

rpmfusion-packager-0.6.2-1.fc26.noarch

Cheers, 

-- 

Sérgio M. B.