I have just installed a pair of AudioEngine speakers and have many problems:

The stock Fedora-34 with pipewire allows some audio output from the speakers but with problems.  However the system with pipewire was so unstable that I was unable to investigate:

So I reverted to pulseaudio.  The audio is now stable, but the speakers are not recognized.  Here are suspicious sections of the starts of the journals for the two setups:

With pipewire:
...
Oct 07 15:50:10 amito kernel: usb 3-14: reset full-speed USB device number 6 using xhci_hcd
Oct 07 15:50:11 amito kernel: usb 3-14.1: new full-speed USB device number 9 using xhci_hcd
Oct 07 15:50:11 amito kernel: usb 3-14.1: New USB device found, idVendor=0a12, idProduct=4007, bcdDevice=14.86
Oct 07 15:50:11 amito kernel: usb 3-14.1: New USB device strings: Mfr=1, Product=2, SerialNumber=3
Oct 07 15:50:11 amito kernel: usb 3-14.1: Product: Audioengine 2+
Oct 07 15:50:11 amito kernel: usb 3-14.1: Manufacturer: Audioengine LLC
Oct 07 15:50:11 amito kernel: usb 3-14.1: SerialNumber: AE202010001A2002
Oct 07 15:50:11 amito kernel: usb 3-14.1: 1:1: cannot set freq 48000 to ep 0x3
Oct 07 15:50:11 amito kernel: hid-generic 0003:0A12:4007.0007: hiddev97,hidraw3: USB HID v1.11 Device [Audioengine LLC Audioengine 2+] on usb-0000:00:14.0-14.1/input2
Oct 07 15:50:11 amito upowerd[2720]: treating change event as add on /sys/devices/pci0000:00/0000:00:14.0/usb3/3-14
Oct 07 15:50:11 amito upowerd[2720]: treating change event as add on /sys/devices/pci0000:00/0000:00:14.0/usb3/3-14
Oct 07 15:50:11 amito mtp-probe[6841]: checking bus 3, device 9: "/sys/devices/pci0000:00/0000:00:14.0/usb3/3-14/3-14.1"
Oct 07 15:50:11 amito mtp-probe[6841]: bus: 3, device: 9 was not an MTP device
Oct 07 15:50:11 amito plasmashell[4490]: UdevQt: unhandled device action "bind"
Oct 07 15:50:11 amito plasmashell[4490]: UdevQt: unhandled device action "bind"
Oct 07 15:50:11 amito plasmashell[4490]: UdevQt: unhandled device action "bind"
Oct 07 15:50:11 amito mtp-probe[6869]: checking bus 3, device 9: "/sys/devices/pci0000:00/0000:00:14.0/usb3/3-14/3-14.1"
Oct 07 15:50:11 amito mtp-probe[6869]: bus: 3, device: 9 was not an MTP device
Oct 07 15:50:11 amito plasmashell[4490]: UdevQt: unhandled device action "bind"
Oct 07 15:50:11 amito kernel: usb 3-14.1: 1:1: cannot set freq 44100 to ep 0x3
Oct 07 15:50:11 amito kernel: usb 3-14.1: 1:1: cannot set freq 44100 to ep 0x3
Oct 07 15:50:11 amito kernel: usb 3-14.1: 1:1: cannot set freq 44100 to ep 0x3
Oct 07 15:50:11 amito kernel: usb 3-14.1: 1:1: cannot set freq 44100 to ep 0x3
Oct 07 15:50:11 amito kernel: usb 3-14.1: 1:1: cannot set freq 44100 to ep 0x3
Oct 07 15:50:11 amito kernel: usb 3-14.1: 1:1: cannot set freq 44100 to ep 0x3
Oct 07 15:50:11 amito kernel: usb 3-14.1: 1:1: cannot set freq 44100 to ep 0x3
...

Using pulseaudio:
...
Oct 07 17:45:46 amito kernel: usb 3-14.1: New USB device found, idVendor=0a12, idProduct=4007, bcdDevice=14.86
Oct 07 17:45:46 amito kernel: usb 3-14.1: New USB device strings: Mfr=1, Product=2, SerialNumber=3
Oct 07 17:45:46 amito kernel: usb 3-14.1: Product: Audioengine 2+
Oct 07 17:45:46 amito kernel: hid-generic 0003:046D:400A.0005: input,hidraw2: USB HID v1.11 Mouse [Logitech Wireless Device PID:400a] on usb-0000:00:14.0-13/input2:1
Oct 07 17:45:46 amito kernel: hub 3-14:1.0: hub_ext_port_status failed (err = -71)
Oct 07 17:45:46 amito kernel: input: Logitech M325 as /devices/pci0000:00/0000:00:14.0/usb3/3-13/3-13:1.2/0003:046D:C52B.0004/0003:046D:400A.0005/input/input13
...
Oct 07 17:45:46 amito kernel: usb 3-14.1: New USB device found, idVendor=0a12, idProduct=4007, bcdDevice=14.86
Oct 07 17:45:46 amito kernel: usb 3-14.1: New USB device strings: Mfr=1, Product=2, SerialNumber=3
Oct 07 17:45:46 amito kernel: usb 3-14.1: Product: Audioengine 2+
Oct 07 17:45:46 amito kernel: usb 3-14.1: Manufacturer: Audioengine LLC
Oct 07 17:45:46 amito kernel: usb 3-14.1: can't set config #1, error -71
...

It would help to know what the various errors mean.

System is Fedora-34 with all updates installed, in detail:
Operating System: Fedora 34
KDE Plasma Version: 5.22.5
KDE Frameworks Version: 5.85.0
Qt Version: 5.15.2
Kernel Version: 5.14.9-200.fc34.x86_64 (64-bit)
Graphics Platform: X11
Processors: 8 × Intel® Core™ i7-4790K CPU @ 4.00GHz
Memory: 15.5 GiB of RAM
Graphics Processor: Mesa DRI Intel® HD Graphics 4600

-- 
Sincerely Jonathan Ryshpan <jonrysh@pacbell.net>

	If God lived on earth, people would break all 
	his windows.