not sure how to trigger it with other applications
but when i click on a cachegrind.out file (xdebug analysis) it opens "kcachegrind" first fine BUT after close it a message "KDEInit could not start '/usr/bin/kcachegrind'" and when i close that error message it's opened again
that's very annoying if you want to open different files and each time have to close two additional windows :-(