Well when I work with typography I preffer to use xelatex for compile
instead of latex or pdflatex. I don't use lualatex yet because in Spanish
we have yet some issues with the correct hyphenation.
Whe need to measure and make proofs with fonts. If you need to use
mathematical symbols then we need a pi font such as Euler (designed by
Hermann Zapf) or another font arranged for LaTeX.
Let me know what is exactly what you need and check few options.
Regards